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if stool is difficult to pass, try again later Consider a footstool to elevate feet during defecation, which may help optimize the anorectal angle Lifestyle measures: Engage in regular physical activity, which promotes healthy bowel motility Avoid prolonged sitting

However, severe side effects are rare, and most side effects can be managed by starting at a lower dose and gradually increasing as tolerated

To date, regulatory authorities have not issued warnings specifically linking tirzepatide to bowel cancer

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Davoli-Ferreira M, Thomson CA, McCoy KD (2021) Microbiota and microglia interactions in ASD