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GLP-1 injections are typically recommended when other treatments, such as metformin, have not provided satisfactory control over blood sugar levels

Stopping cold turkey typically leads to rapid appetite return and significant weight regain within months

After 40 weeks, people taking retatrutide had average HbA1c reductions of around 1.7 to 1.9 percentage points

Admittedly these data refer to the huge heart failure studies and might not be valid without any exception (Tamargo et al

Semaglutide is the established standard with three FDA approvals, massive clinical evidence, and proven cardiovascular outcomes

In this brief review, we summarise the current evidence highlighting how metformins benefits are likely to be caused by a variety of molecular mechanisms