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Clinical trials show Retatrutide achieves an average 24.2% body weight reduction over 48 weeks, with female participants losing approximately 25.3% of their body weight at the 12mg dose

Conversely, treatment of MDAMB231 cells with an OGT inhibitor OSMI1 led to a marked reduction in YAP OGlcNAcylation, diminished interaction with EIF3H as determined by both coimmunoprecipitation and PLA assay, and a decrease in YAP protein levels (Figure 3GI

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