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Safety Profile and Side Effects Reported in the Trial The most common adverse effects were gastrointestinal particularly nausea, vomiting, and diarrhoea occurring most frequently during dose escalation and generally mild to moderate in severity

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GLP-1 strongly promoted cAMP accumulation but did not stimulate insulin secretion in low-glucose (2 mM) state, indicating glucose-induced signaling as the main pathway (Fig

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