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For the researchers, this finding raised questions about implications for aging, frailty and fitness in the long term

The process boosts glucose-dependent insulin production while reducing glucagon release from the pancreatic -cells, resulting in decreased blood sugar levels and a minimized risk of hypoglycemia because of increased insulin and decreased glucagon secretion [13]

Malik, J

N Engl J Med (2015) 373(22):211728

(2017) Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species

Despite the observational nature of this pharmacovigilance study and the inherent limitations of the FAERS database, our preliminary findings in this work could provide a better basis for understanding the potential psychiatric AEs that may occur with GLP-1 RA treatment, assisting clinicians to focus on these AEs and provide early intervention for optimal risk management
