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Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production ( In contrast, some postbiotics may suppress GLP-1 signaling

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John Oldham, a bariatric surgeon with Baptist Health, said for 20% of patients taking Ozempic and similar prescriptions, the side effects are severe enough that they stop taking the drug altogether