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Tirzepatide was associated with greater relative lean body mass (LBM) loss than semaglutide at each measured time point, with excess LBM losses of 1.1%, 1.5%, 1.3% and 2% at 3, 6, 9 and 12 months, respectively

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Conclusions Regardless of the GLP-1 RAs used, it is apparent that GI AEs are significant and highly prevalent

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