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Understanding common side effects 1 The most common adverse reactions, reported in 5% of patients treated with RYBELSUS are: nausea abdominal pain diarrhea decreased appetite vomiting constipation In the pool of placebo-controlled trials, the majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation

The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity

Wegovy (weight loss indicator): Before first use, refrigerate (36F-46F, 2C-8C)

This information should be interpreted alongside clinical biomarkers and medical history, not in isolation

Patients with cirrhosis were older and in care longer than patients without cirrhosis (Table 1)

Overall, this phase 1b trial demonstrates that combined cagrilintide and semaglutide therapy is safe, well-tolerated, and offers clinically meaningful weight loss compared to placebo, warranting further investigation for weight management in obesity