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CDT (2012) 13:10315
What Makes a Patent Thicket and Why AbbVies Humira Strategy Lasted So Long AbbVies defense of adalimumab (Humira) through a patent thicket of more than 130 secondary patents is the most studied example of IP lifecycle management in pharmaceutical history
Its structure includes specific amino acid modifications and a fatty acid side chain that extends its duration of action, allowing for once-weekly dosing in approved medical products
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