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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

This combination makes eating in a calorie deficit feel much harder than it did while taking GLP-1

By affecting brain structure and function, GLP-1 agonists have shown potential in addressing cognitive deficits linked to bipolar disorder, offering a more complete approach to treatment

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doi: 10.1016/j.psyneuen.2020.104720

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Han J., Wu J., Silke J