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Dulaglutide administration at doses of 50, 100, and 150 g/kg significantly reduced colon weight, the weight-to-length ratio, both macroscopic and microscopic colonic changes in inflammation, and decreased serum CRP and LDH levels

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This suggests that, despite their shared hydrophobic characteristics, peptides with appropriately tailored sequences can demonstrate specificity toward the TMD of a targeted receptor 14

In a 30-week triple-blind, placebo-controlled clinical investigation, Exenatide caused much more weight loss than placebo