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Although there are no published randomized trials specifically on microdosing tirzepatide at this time, the potential advantages are based on theoretical extensions of current tirzepatide research and patient anecdotes

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Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients

The metabolic clearance occurs by proteolytic cleavage of the tirzepatide peptide backbone, -oxidation of the C20 fatty diacid moiety, and by amide hydrolysis