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Midler DA, Midler TY, Liang SS, Kam PCA

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doi: 10.3949/ccjm.84a.16094

Abstract Background Glucagon-like peptide-1 receptor agonists, originally developed for managing type 2 diabetes, have gained attention for their weight-reducing and broader biological effects

These drugs work by mimicking the action of the hormone GLP-1, which stimulates insulin secretion, suppresses glucagon secretion, and slows gastric (stomach and intestine) emptying

Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]
