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"The more you use these drugs, the more weight loss you'll see until it plateaus, right?" Chen said

Regarding drug interactions with MS disease-modifying therapies, there are no known direct pharmacokinetic or pharmacodynamic interactions between tirzepatide and commonly used DMTs such as interferons, glatiramer acetate, natalizumab, fingolimod, or ocrelizumab

For MOTS-c, the endpoints should be more metabolic than membrane-focused: fasting glucose, insulin sensitivity markers, body-weight trend, waist measurement, training tolerance, recovery, liver-enzyme context, lipid markers, and exercise capacity

Ethics declarations Consent to participate Blank urine samples were provided with informed consent as part of routine workplace drug testing

The result is a cycle where excess weight lowers testosterone, and lower testosterone makes it harder to lose weight and build muscle

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