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How Semaglutide Injections Damage Blood Vessels When a needle penetrates the skin during a semaglutide injection, it can puncture small blood vessels (capillaries) in the subcutaneous tissue layer

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Sometimes, even with treatment, problems can happen that can upset how well you are managing your condition

While Ozempic and certain weight loss medications contain the same active ingredient, Ozempic is targeted specifically for diabetes management, not for weight loss

However, a recent clinical study reported that the infusion of exendin 9-39, a GLP-1R antagonist, did not affect ad libitum food intake in post-RYGB patients, although the authors also reported a concomitant increase in plasma levels of the anorexigenic hormone PYY (discussed below), which might offset the orexigenic effect of GLP-1R antagonism (94)