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They can be treated if they occur (sometimes with medication to dissolve stones or with surgery if severe)

GLP-1 slows gastric emptying and signals fullness to the brain, while GIP plays a complementary role in how the body processes fat and glucose

Results from the TRIUMPH-1 Phase 3 trial show participants on 9mg losing an average of 23.7% of body weight, and those on 12mg losing 25% at 80 weeks overall with the subgroup of participants escalated to maximum tolerated dose achieving the full 28.3% Synedica Retatrutide weight loss result

A shorter half-life necessitates more frequent administration to maintain a steady, therapeutic level

Drink plenty of fluids to reduce the risk of dehydration

Some insurance may cover part or all of the cost of these medications, especially if a physician deems them necessary for managing obesity-related health conditions