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5.4 Gastrointestinal Side Effects and Nutrient Loss Nausea and vomiting are well-documented adverse effects. Persistent vomiting or diarrhoea may: Increase electrolyte loss Reduce caloric intake Reduce dietary diversity However: These effects are typically transient and dose-related

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Oral glucose challenge and GLP-1 measurement Oral glucose challenge and plasma GLP-1 measurement were conducted 24 weeks after the initial treatment in DIO mice

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It has the largest rotation surface area and a consistent subcutaneous fat layer

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Current practice While authoritative health and medical entities recommend comprehensive lifestyle modification as part of the treatment plan for obesity, the use of such therapies prior to or to support GLP-1 use is not widespread in practice

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Numerous Mounjaro lawsuits alleging severe side effects have been consolidated in a federal multidistrict litigation (MDL)

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, Fraterrigo, G

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