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GLP-1 receptors are distributed throughout the gastrointestinal tract at concentrations five to eight times higher than in the hypothalamus, where appetite suppression occurs

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Last reviewed: July 1, 2026 Last updated: July 1, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry

According to the FDA prescribing information for Zepbound, in the SURMOUNT-1 trial, cholelithiasis was reported in 2.5% of patients receiving tirzepatide compared to 1.0% of patients on placebo

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