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Therefore, if GLP-1 RA treatment specifically increases the risk of pancreatitis in this vulnerable population, such an effect would likely remain undetected in randomized trials

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A review of the safety and efficacy data for insulin glargine 300 units/ml, a new formulation of insulin glargine
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In addition to its local gut functions, the gut microbiota also produces bioactive metabolites, such as short-chain fatty acids (SCFAs), lipopolysaccharides (LPS), secondary bile acids, and generates precursors of uremic toxins, targeting systemic distant organs such as the liver, kidney, and cardiovascular system [5, 6]

Hepatology 51 (5), 15841592
