tirzepatide alcoholism attenuates dopamine reward signaling and suppresses alcohol drinking and relapse-like behaviors in rodents Alcohol & Mounjaro: Safe Drinking
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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Soroceanu L., Gillespie Y., Khazaeli M.B., Sontheimer H

At least half -- and up to two-thirds -- of GLP-1 drug users discontinue them within a year, with cost frequently cited as the reason

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More microglia are in an inflammatory phenotype as we age, they produce more pro-inflammatory cytokines (IL-6, TNF, IL-1), microglia produce fewer anti-inflammatory mediators (IL-10, BDNF, inhibitor of NF-kappa beta), and they have more of an exaggerated response to basic challenges
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