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Food and Drug Administration (FDA) approved Mounjaro (tirzepatide) injection, Eli Lilly and Company's (NYSE: LLY) new once-weekly GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes

Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial

This data proves valuable for practitioners managing patients who frequently discuss medication tolerability concerns on platforms like Reddit, specifically for those who are non-responders to GLP-1

However, its usefulness for progressed DKD and established CVD remains unclear

Every expert agrees that the most common side effects of GLP-1s are constipation

In 2010, approximately 1.28 million prescription items were dispensed in England, according to NHS England