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When metabolic stress hits the cell (low energy, high oxidative load, glucose imbalance), MOTS-c is released from the mitochondria, enters the cytoplasm, and ultimately translocates into the cell nucleus where it regulates expression of stress-adaptation genes

Statistical Analyses All statistical analyses were performed using SAS versions 9.3 or 9.4 (SAS Institute, Cary, NC, USA)

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dapagliflozin as add-on therapy in patients with type 2 diabetes mellitus based on renal function: a pooled analysis of two randomized controlled trials Young Sang Lyu, Sangmo Hong, Si Eun Lee, Bo Young Cho, Cheol-Young Park Cardiovascular Diabetology.2024;[Epub] CrossRef A 52week efficacy and safety study of enavogliflozin versus dapagliflozin as an addon to metformin in patients with type 2 diabetes mellitus: ENHANCEM extension study Tae Seo Sohn, KyungAh Han, Yonghyun Kim, ByungWan Lee, Suk Chon, InKyung Jeong, EunGyoung Hong, Jang Won Son, JaeJin Na, Jae Min Cho, Seong In Cho, Wan Huh, KunHo Yoon Diabetes, Obesity and Metabolism.2024

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Definition, epidemiology and classification of diabetes in children and adolescents