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DPP-4 Inhibitors and BP Regulation: Potential Mechanisms Primary hypertension is a cardiovascular syndrome characterized by elevated BP, and represents the leading cause of cardiovascular disease and stroke and the primary cause of death and disease burden worldwide ( Immunological Mechanisms of DPP-4i Upon Hypertension Many chronic diseases are closely related to non-specific inflammatory processes, such as insulin resistance, metabolic syndrome, T2DM, and coronary heart disease, which are associated with increased infiltration and cell proliferation of immune cells and the elevated release of inflammatory mediators