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10.1016/s0140-6736(23)01053-x

Heres why: Wait Until Weight Stabilizes: Treating too early means continued volume loss after treatment Unpredictable final facial structure makes planning difficult May require additional, unnecessary treatments Ideal Timing: Within 5-10 pounds of goal weight Weight stable for 2-3 months No longer actively losing weight rapidly Completed or nearly completed GLP-1 medication course Exception: Proactive Treatment Some patients benefit from early intervention if: Theyre losing weight very slowly (under 1 pound weekly) Facial aging is causing significant distress They understand additional touch-ups may be needed Theyre combining restoration with ongoing maintenance Real Patient Success: Ozempic Face Transformation in Seven Oaks Jennifer, 52, healthcare administrator from Seven Oaks After losing 65 pounds on Wegovy, I finally fit into clothes I hadnt worn in 20 years
Renal contributions Adjusts sodium reabsorption and excretion Modulates urine sodium concentration in response to volume status Excretes excess free water to maintain normal plasma sodium Hormonal regulation Antidiuretic hormone (ADH) increases water reabsorption in the kidneys Excess ADH leads to water retention and dilution of sodium in the blood Inappropriate antidiuretic hormone secretion disrupts normal feedback mechanisms, causing persistent water retention despite low plasma sodium Clinical relevance Impaired kidney function, such as in chronic kidney disease, limits the ability to excrete free water Even modest fluid intake can therefore lead to hyponatremia in these patients Etiology and Risk Factors Causes of Hyponatremia Hyponatremia arises from a wide range of clinical conditions that disrupt the normal balance between water and sodium

79 conducted another systematic review with categorical analysis, finding that patients in the malabsorptive surgery group (including RYGB and biliopancreatic diversion) experienced significant BMD reduction one year postoperatively, particularly at the hip and spine

For a 180-pound person, that translates to roughly 98-131 grams of protein per day
Drink plenty of fluids (without alcohol)
