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Together, these findings provide evidence for the beneficial effects of incretin-based therapies for kidney function in populations without diabetes

Clinical trial data from the STEP 1 and SURMOUNT-1 trials show that patients typically achieve 1015% total body weight loss with semaglutide 2.4 mg weekly (Wegovy) and 1520% with tirzepatide 1015 mg weekly (Zepbound) over 1218 months

It produces faster side effects

For psyllium, this means approximately 1.5 grams (half a standard dose)

Patients with high FTO rs9939609 risk alleles benefit from more aggressive appetite suppressiontirzepatide's mechanismwhile those with favorable GLP1R variants achieve results with semaglutide's focused approach

In this guide, well break down what GLP-1s are, how they work, the key differences between popular options, and how to decide which one could be the right fit for you as you begin your journey to a new you