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This hormone activates GLP-1 receptors in the enteric nervous system and through vagal pathways that influence digestive function

13 Regarding the application of GLP-1RAs in MASLD, current understanding suggests they can serve as additional pharmaceutical options in lifestyle management for patients with complications like obesity and T2DM

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In addition, denaturation, isolation, and elimination of the GLP-1R N-terminal domain result in loss of affinity for the peptide25)