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Semaglutide is a groundbreaking medication

Sources of uncertainty originate from the panoply of glycemic targets, the complexity of drug therapy, the choice of the first drug, the ideal sequence of drugs after the first drug failure, the possible harms of anti-hyperglycemic drugs, the outcomes of treatment (surrogate versus clinical) and the hierarchy of risk factors to treat for preventing the vascular complications

100 , 101 While oral formulations have demonstrated acceptable tolerability overall, gastrointestinal side effects remain common and may occur at similar or slightly higher rates than with injectable agents

Novo Nordisk markets the drug Wegovy, available as an injectable and once-a-day pill

These drugs are primarily approved for treating type 2 diabetes, so coverage is usually only available if a patient with PCOS also has type 2 diabetes or obesity as a related condition

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