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lag-2(secreted) is based on the design of the same transgene from Fitzgerald and Greenwald, 1994, with the 20aa GPI attachment sequence from vab-2 /Ephrin [28] added to the C-terminus

GLP-1 is rapidly degraded by an enzyme named dipeptidyl peptidase-IV (DPP-4), converting to bioinactive products GLP-1 (9-36) and GLP-1 (9-37) ( GLP-1 exerts its function by binding to GLP-1R and is involved in the development and progression of many diseases ( GLP-1R agonists (GLP-1RAs) are a group of GLP-1 analogues that are resistant to DPP4-mediated degradation, working through activating GLP-1R and its downstream signaling ( The expression of GLP-1R remains controversial due to the lack of specific antibody against GLP-1R, with most of the literatures using qPCR to detect mRNA levels ( 2 GLP-1 in regulating immune system 2.1 The role of GLP-1 in innate immune cells Recent studies have demonstrated that GLP-1 and its analogues exert regulatory functions in innate immune cells, especially macrophages

Diabetologia 65 , 15411554 (2022)

A meta-analysis of 45 randomized controlled trials observed a trend toward increased risk of thyroid dysfunction in patients treated with GLP-1 receptor agonists, although the findings did not reach statistical significance