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This expansion is underpinned by the broadening of approved indications beyond glycemic control to include cardiovascular risk reduction and weight management in type 2 diabetes patients, as well as the rapid uptake of oral formulations that improve patient adherence
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It is also possible that the peripheral secretion indirectly regulates the level of activation of brain neuronal circuits expressing the GLP-1 receptor

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Most earlier drugs targeted a single pathway and ran into safety or efficacy hurdles
