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To add some data to this important discussion on oral GLP-1 research, I pulled an evidence-backed synthesis from Cheiron on the scientific and clinical challenges in developing effective oral GLP-1 therapies: [ Its a compelling look at why this complex science cant be rushed or shortcut

[DOI] [PubMed] [Google Scholar] 172.Saxena, A

Given the critical and pleiotropic roles that TGF- signaling plays in normal development, tissue homeostasis, and immunomodulation, broad inhibition of TGF- signaling often results in unacceptable toxicity

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