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The LEADER-6 study shown substantial cardiovascular advantages of liraglutide in high-risk patients, while SUSTAIN-6 revealed a significant decrease in cardiovascular event-related mortality with subcutaneous semaglutide (Verma et al

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"The next step is to investigate whether the medication reaches the joints in sufficient quantities and actually reduces inflammation in the joints." About the Study The research was a translational clinical biomarker study that examined paired blood and joint fluid samples from patients with inflammatory arthritis, including rheumatoid arthritis and spondyloarthritis

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0% with placebo, suggesting promising early efficacy signals [49]

subsequently confirmed this association in a large multicenter database study of 37.1 million adults, but the incidence was low at 14.5 per 100,000 person-years among semaglutide users, and there was only a modest increase in risk attributable to semaglutide (90)