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Whilst the pathogenesis of PD remains unclear, impaired insulin signaling appears detrimental in the development and progression of PD-related neurodegeneration

Effect of Sodium Glucose Cotransporter 2 Inhibitors on Cardiac Function and Cardiovascular Outcome: A Systematic Review
Most side effects appear in the first 1-2 weeks and diminish as the body adjusts

Regarding serious renal events, although the combination showed a lower incidence (1.4 vs 2.0 events per 1000 person-years), the confidence interval was wide (HR 0.67

JAMA Pediatr (2022) 176(5):45260

[DOI] [PubMed] [Google Scholar] 31.Ban K., Noyan-Ashraf M.H., Hoefer J., Bolz S.-S., Drucker D.J., Husain M
