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If you've recently been prescribed a GLP-1, or are just learning how they work, it's important to know how to store them properly

Mechanism deep dive: Attia #337 with Ralph DeFronzo, insulin resistance masterclass What this means in practice For most people, the fastest return comes from the lifestyle foundations: (1) movement, (2) fat loss where appropriate, and (3) reducing glucotoxicity

Patients should be advised to: Rotate injection sites to prevent lipohypertrophy (lumps under the skin) Store unused pens in the refrigerator (28C)

Precautions: If you are pregnant, nursing, have a medical condition or are taking any medication, consult your physician before use

Beyond appetite suppression, GLP-1 RAs improve systemic glucose homeostasis through pancreatic and extra-pancreatic mechanisms

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