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The findings were published in a paper called Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes. The researchers examined data from more than 1.5 million people with type 2 diabetes

We emulated and benchmarked against two cardiovascular outcome trials (reference trials), SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) in a pair of cohort studies

These biomarkers could possibly be used to monitor and document disease progression

Relation of elevated heart rate in patients with heart failure with reduced ejection fraction to one-year outcomes and costs

Educate patients on the signs and symptoms of hypoglycemia [see Warnings and Precautions (5.4)]

They may also slightly increase heart rate