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FDAs Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, updated Dec

[4] Practical guidance for patients and healthcare professionals: GLP-1 receptor agonists should be prescribed according to their licensed indications (type 2 diabetes and, for specific agents, weight management) Patients with diabetes and cognitive concerns should ensure optimal management of all cardiovascular risk factors, including blood pressure, cholesterol, and glycaemic control Lifestyle interventionsincluding regular physical activity, Mediterranean-style diet, cognitive engagement, and social interactionremain the most evidence-based approaches to reducing dementia risk Anyone experiencing memory problems, confusion, or cognitive changes should contact their GP for proper assessment and potential referral to a memory clinic Seek urgent medical attention for sudden confusion, rapidly worsening symptoms, stroke-like symptoms, or cognitive changes following head injury Patients should not discontinue or commence GLP-1 receptor agonists based solely on potential cognitive effects without medical consultation The field of GLP-1 research in neurodegeneration represents an exciting area of investigation, but clinical recommendations must await robust trial evidence demonstrating clear benefit and acceptable safety profiles in relevant populations

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A meta-analysis and systematic review encompassing 82 randomized controlled trials revealed a significant association between DPP-4 inhibitors and an increased risk of cholecystitis, while no such association was found with an increased risk of cholecystolithiasis or other biliary diseases ( Liyun He et al