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Semaglutide may also be prescribed off-label for other uses

doi: 10.1016/j.jdiacomp.2022.108332 138 RosenstockJFriasJJastreboffAMDuYLouJGurbuzSet al

Furthermore, we demonstrated in animal studies that GLP-1 secretion induced by these factors does not evoke aversive behaviors, unlike GLP-1RAs, and promotes satiation, thereby suppressing hyperphagia and weight gain induced by a high-fat diet

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met + SU): a randomised controlled trial

After adjusting for residual confounding, the difference in weight loss between those receiving tirzepatide vs semaglutide was 2.0% (95% CI, 2.1% to 1.8%) at 3 months, 3.2% (95% CI, 3.5% to 3.0%) at 6 months, and 5.1% (95% CI, 5.8% to 4.3%) at 12 months

It is typical that the weight returns within two years unless the changes endure past the medication period