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This work was supported by the Italian Ministry of Healths Ricerca Corrente funding to the IRCCS Humanitas Research Hospital

As GLP-1s have moved towards weekly dosing, users are less likely to experience the desensitisation that comes from repeated exposure

Neither Piper nor Gala performs this stratification both start from a population-average titration schedule and adjust based on subjective tolerability over the first 812 weeks

However, it is extremely important to have a strong focus on having a very nutrient-dense diet if on a GLP-1 [because] there is less opportunity to fit all the nutrients in. The goal for anyone on a GLP-1 is to eat enough food to meet their nutrient needs, but supplements may offer support

The analysis draws on current literature examining efficacy, safety, and real-world implementation barriers within the primary care context

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