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Therefore, basolateral LPL access to chylomicrons may be required

But there may be positive effects as well

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For example, specific trials with semaglutide have reported lean mass losses anywhere from 0% to 40% of total weight lost, though fat loss generally outweighs muscle loss, resulting in a higher proportion of lean mass relative to overall body weight

This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]
