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[1,2] When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount

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The total number of new patients who started renal replacement therapy (RRT) for ESRD increased from 10,000 in 2011 to 18,642 in 2019 [4], and the proportion of patients with DM as the underlying cause of ESRD increased from 19.5% in 1992 to 50.6% in 2012 [5], making DM the most common cause of ESRD in Korea [4]

This leads to a decreased calorie intake and sustainable weight loss

Cell Metab 10:167177 Cubeddu LX, Bnisch H, Gthert M et al (2000) Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT 3 receptors