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This gene is responsible for the protein aldo-keto reductase which helps reduce progesterone to its inactive form 20--hydroxyprogesterone
There is a psychological component too
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Real-world data from a Truveta study of over 18,000 patients found that tirzepatide users achieved greater weight loss at 12 months compared to semaglutide users, consistent with the SURMOUNT-5 findings [4]
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a DPP-IV inhibitor
