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glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP‑1 Therapy Improves Atrial Fibrillation

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RCT SCALE Study - Liraglutide vs Placebo for Weight Loss in Overweight Nondiabetic Adults, NEJM (2015) [PubMed abstract] The SCALE study enrolled 3731 overweight adults who did not have diabetes Main inclusion criteria BMI 30

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

10.1093/eurheartj/ehae508 88

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

Diabetes 53 , 654662 (2004)

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

In addition, GLP-1 RAs were not associated with increased risk of suicide death, self-harm, or incident depression and anxiety-related disorders

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

Moretto et al., 2008

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

Pectin stimulates GLP-1 secretion in the isolated perfused rat colon [304] but not in the isolated rat ileum [250]

glp-1 receptor agonist atrial fibrillation risk Glucagon-like peptide 1 agonists: cardiovascular benefits and mechanisms of action GLP1 Therapy Improves Atrial Fibrillation

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