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2012;14(Suppl

However, in contrast to GIP, GLP-1 has been found to be consistently elevated in response to both RYGB and VSG

S., Kliemann, N., Masoudkabir, F., Noll, M., Mohammadifard, N., Sarrafzadegan, N., & de Oliveira, C

This result suggests that semaglutide has cardioprotective effect independent of any substantial glucose lowering properties

10.1371/journal.pone.0012226 30

It is very plausible that these patients that have poor blood glucose regulation have faults in their upper digestive tract and those bitter receptors and the sweet receptors that are regulating the production of the GIP and the GLP-1 may not be doing their thing properly or the L cells may be receiving the signal but are not healthy enough to produce enough GLP-1