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The use of semaglutide was associated with improved clinical symptoms, physical activity, exercise function, quality of life, and more significant weight loss than the placebo group

In hepatocellular carcinoma models induced by DEN combined with either high-fat/high-carbohydrate or low-fat/low-carbohydrate diets, lean m/db mice, and MCD- or CDE-induced liver injuryas well as in human models, exenatide activation of the GLP-1RcAMPPKAEGFRSTAT3 pathway suppressed oncogenic signaling, limited tumor cell growth, and enhanced apoptosis, resulting in a marked reduction in tumor progression (Zhou et al., 2017)

doi: 10.1007/s11897-021-00529-8 27 HiraizumiMAkashiTMurasakiKKishidaHKumanomidouTTorimotoNet al

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doi:10.2337/dc17-1956 Bethel MA, Patel RA, Thompson VP, Merrill P, Reed SD, Li Y, et al

While the first GLP-1 was approved by the FDA more than 20 years ago, to treat Type 2 diabetes, the use of these drugs took off in 2021 when Novo Nordisk received approval for a semaglutide drug to treat obesity, with the brand name Wegovy