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Byrd RA, et al

Effects of tirzepatide versus insulin glargine on cystatin C-based kidney function: a SURPASS-4 post hoc analysis

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268 The latter includes both central homeostatic (energy-intake-focused) and non-homeostatic (reward-focused) regulation of food consumption in the hypothalamus and nucleus of the solitary tract, 268-271 influenced by a relatively small amount of GLP-1 that crosses the blood-brain barrier and, more notably, GLP-1 modulation of vagal afferent neurons

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Chronic Inflammation: Which can hinder metabolic flexibility