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In 1986, Danish scientist Jens Juul Holst discovered that the gut hormone GLP-1 stimulates insulin and suppresses appetite

In addition, the JNK-1 signaling pathway also results in serine phosphorylation of IRS-1 and inflammatory gene transcription via transcription factor activator protein 1 (AP1) [19]

Anti-Thrombotic Effects GLP-1 agonists decrease platelet aggregation and tissue factor expression and therefore lower the likelihood of thrombotic events [40]

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Both are effective, but tirzepatides dual mechanism may benefit some patients more

This lack of FDA approval means they haven't undergone the rigorous testing for safety, efficacy, and quality that regulated medications do