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However, there was no clear explanation for the neutral cardiovascular profile of lixisenatide, rather than the expected cardioprotective effect

Both drug classes have been shown to confer clinical benefits such as glycaemic control, body mass reduction, and improved systolic blood pressure and lipid profiles, which may collectively contribute to their cardiorenal protective effect.32 However, these drug classes use different mechanisms to achieve these effects

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While gastroparesis caused by medications such as Ozempic is typically reversible, there is some evidence to suggest that it may continue for some time after the drug is discontinued

hence, its dose should not be changed in renal impaired patients [24]

This daily subcutaneous injection established liraglutide as a well studied medication with cardiovascular benefits demonstrated in the LEADER trial