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Known commercially as Sirturo, the drug won approval in 2024 as part of combination therapy in adults and children 5 years and older and weighing at least 15 kg, with pulmonary TB due to Mycobacterium tuberculosis resistance to at least rifampicin and isoniazid

Oral administration, while avoiding needles, might introduce concerns related to gastrointestinal upset, unknown interactions with other oral compounds, or the safety profile of novel excipients used in oral formulations

For each study included in the review, we extracted detailed information on the study design, sample size, participant characteristics, type and dosage of GLP-1 RA used, and the key outcomes measured

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Patients were matched 1:4 to non-treated patients using a propensity score (PS) model
