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PKA further activates the cAMP-response element binding protein (CREB) and the transducer of regulated CREB activity 2, leading to enhanced insulin receptor substrate 2 gene expression and promotion of -cell proliferation (26)
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All covariates were assessed at baseline (index date) and did not vary over time

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Effects of glucose-lowering agents on surrogate endpoints and hard clinical renal outcomes in patients with type 2 diabetes
Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes
