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The story was revived in the 1960s when oral administration of glucose was found to produce a greater increase in insulin secretion than the same dose administered intravenously, suggesting that release of a gut hormone was priming the pancreas for insulin secretion in response to a meal

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Table of Contents Understanding Mounjaro and Its Gastrointestinal Effects Mounjaro (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus and, more recently, for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with weight-related comorbidities

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