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glp-1 drugs depression Study: Weight loss drug may aid in treating Ozempic: GLP-1s Linked to 42%
Description
MS, medial septal nucleus

The approved DPP-4 inhibitors demonstrate a high specificity toward DPP-4 and do not inhibit other peptidases

Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure

A long-acting glucose-dependent insulinotropic polypeptide receptor agonist improves the Gastrointestinal tolerability of glucagon-like peptide-1 receptor agonist therapy

In fact, this effect isnt unique to GLP-1 RAs

10.1016/j.diabres.2015.07.015 53 SunF.WuS.WangJ.GuoS.ChaiS.YangZ.et al (2015b)
